5 Amino 1MQ

5‑Amino‑1MQ – NNMT Inhibitor for Metabolic Research

5‑Amino‑1MQ is a small‑molecule NNMT (nicotinamide N‑methyltransferase) inhibitor widely used in experimental models of metabolism, adiposity, and cellular energy regulation. By targeting NNMT, a key enzyme involved in nicotinamide methylation and NAD⁺ availability, 5‑Amino‑1MQ allows researchers to explore how shifting the NNMT–NAD⁺–SIRT1 axis may influence fat storage, energy expenditure, and muscle function. (https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113/)

Key features

• Mechanism‑driven design: 5‑Amino‑1MQ inhibits NNMT, a metabolic “bottleneck” implicated in reduced NAD⁺ levels, impaired mitochondrial output, and increased adipocyte size in preclinical models. https://pmc.ncbi.nlm.nih.gov/articles/PMC8337113/

• Metabolic research focus: Commonly used to investigate fat mass reduction, changes in adipocyte morphology, resting energy expenditure, and glucose/insulin dynamics in animal and in vitro systems.

• NAD⁺ and mitochondrial function: NNMT inhibition has been associated with higher intracellular NAD⁺, enhanced mitochondrial efficiency, and improved muscular performance in preclinical work.

• Convenient small‑molecule format: As a non‑peptide research compound, 5‑Amino‑1MQ is typically explored in oral or systemic models where investigators want to probe whole‑body metabolic effects.

  
  

Research applications

5‑Amino‑1MQ is being studied in:

• Obesity and metabolic‑syndrome models examining fat‑mass reduction, adipocyte size, and lipid storage pathways.

• NAD⁺‑centric research on mitochondrial function, cellular energy production, and age‑related changes in metabolism and body composition.

• Performance and sarcopenia models assessing muscle strength, endurance, and recovery in conjunction with exercise interventions.

  
  

Recommended handling

• For laboratory research use only, by qualified professionals.

• Store in a cool, dry environment away from direct light; follow your lab’s standard operating procedures for small‑molecule handling.

• Refer to current literature and internal protocols for model‑specific dosing and study design.

  
  

Important disclaimer

All compounds sold by Rocky Peptide Chain, including 5‑Amino‑1MQ, are for research use only. They are not intended for human consumption, medical use, diagnostic use, or treatment of any disease or condition. No therapeutic or performance claims are made or implied. Researchers are solely responsible for appropriate handling, dosing design, and compliance with all applicable regulations.