MOTS-C

MOTs‑C – Mitochondrial‑Derived Peptide for Metabolic and Longevity Research

MOTs‑C (Mitochondrial ORF of the 12S rRNA type‑C) is encoded by the mitochondrial 12S rRNA gene and functions as a stress‑responsive signaling peptide that links mitochondrial status to nuclear gene expression and whole‑body metabolism. Under metabolic stress, this mitochondrial peptide can translocate to the nucleus, activate AMPK‑centered pathways, and reprogram metabolic and stress‑response genes, making it a key tool in models of insulin resistance, exercise adaptation, and healthy aging.

Key features

• AMPK‑driven metabolic regulation: MOTs‑C activates the AMPK pathway and modulates folate–purine metabolism, enhancing glucose uptake, glycolysis, and fatty‑acid oxidation while improving insulin sensitivity and energy homeostasis.

• Exercise‑induced myokine: Human and animal studies show that MOTs‑C levels rise in skeletal muscle and circulation in response to exercise, where it improves exercise capacity, muscle metabolic flexibility, and performance across age groups.

• Anti‑inflammatory and cytoprotective actions: Preclinical work demonstrates reductions in pro‑inflammatory cytokines, improved cellular stress resistance, and protection against metabolic and oxidative injury in multiple tissues.

• Bone and multi‑tissue relevance: MOTs‑C promotes osteoblast proliferation and mineralization, inhibits osteoclast formation, and favorably influences adipose tissue, liver, and cardiovascular metabolism, broadening its utility beyond classic metabolic models.

  
  

Research applications

MOTs‑C is employed in experimental systems exploring:

• Obesity, insulin resistance, and type 2 diabetes, evaluating glucose tolerance, insulin sensitivity, lipid handling, and weight/metabolic outcomes.

• Exercise physiology and performance, where investigators assess endurance, muscle function, mitochondrial biogenesis, and exercise‑induced MOTs‑C signaling.

• Aging, longevity, and age‑related disease models, examining how MOTs‑C affects metabolic resilience, inflammation, cardiovascular risk, and functional decline with age.

• Bone and tissue‑remodeling biology, including osteogenesis, bone‑remodeling balance, and cross‑talk between skeletal, adipose, and metabolic tissues.

  
  

Recommended handling

• For controlled laboratory research use only, by qualified professionals.

• Store in a cool, dry environment away from light; follow institutional SOPs for peptide storage, reconstitution, aliquoting, and disposal.

• Investigators should consult current literature when designing dosing regimens, timing relative to feeding or exercise, and outcome measures for metabolic, performance, or aging endpoints.

  
  

Important disclaimer

All compounds sold by Rocky Peptide Chain, including MOTs‑C, are for research use only. They are not intended for human consumption, medical use, diagnostic purposes, or treatment of any disease or condition. No claims are made or implied regarding weight loss, performance enhancement, anti‑aging, or therapeutic benefit. Researchers are solely responsible for appropriate handling, experimental design, and compliance with all applicable regulations.